SGOT Full Form “Serum Glutamic Oxaloacetic Transaminase.”
Explanation of SGOT:
Serum Glutamic Oxaloacetic Transaminase, commonly known as SGOT or AST (Aspartate Aminotransferase), is an enzyme found predominantly in the liver, heart, muscles, and other organs. It plays a crucial role in cellular metabolism and is involved in the transfer of an amino group from aspartate to alpha-ketoglutarate, leading to the formation of glutamate and oxaloacetate.
Clinical Significance of SGOT:
SGOT is an essential biomarker used in medical diagnostics to evaluate the health of the liver and other organs. When cells of the liver or heart are damaged or injured, SGOT is released into the bloodstream, leading to an increase in its blood levels. Therefore, elevated SGOT levels in blood tests can indicate potential liver or cardiac problems.
Liver Function Tests (LFTs) often include SGOT measurements alongside other liver enzymes, such as SGPT (Serum Glutamic Pyruvic Transaminase or ALT) and alkaline phosphatase, to assess liver health and identify liver diseases or damage. Common liver conditions that may cause elevated SGOT levels include:
Hepatitis: Inflammation of the liver caused by viral infections (e.g., hepatitis A, B, C) or other factors.
Cirrhosis: Scarring of the liver tissue due to long-term liver damage, often associated with chronic alcohol consumption or certain diseases.
Liver Injury: Any trauma or damage to the liver, such as drug-induced liver injury, toxins, or infections.
Fatty Liver: Accumulation of excess fat in the liver, often associated with obesity and metabolic disorders.
Liver Cancer: Malignant tumors affecting the liver can cause an increase in SGOT levels.
It’s important to note that elevated SGOT levels alone are not specific to a particular condition and need to be interpreted alongside other clinical findings and tests to make an accurate diagnosis. Additionally, certain medications, strenuous physical activity, and other factors can also cause temporary elevations in SGOT levels.
SGOT, short for Serum Glutamic Oxaloacetic Transaminase, is an enzyme found in various organs, with higher concentrations in the liver and heart. Its measurement in blood tests is a valuable tool in assessing liver health and detecting liver and cardiac disorders. Elevated SGOT levels may indicate liver damage or injury, but further evaluation and tests are necessary to determine the underlying cause accurately. Medical professionals use SGOT results in conjunction with other clinical data to make informed diagnoses and provide appropriate medical care.